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Influence of electroacupuncture on the expression of AMPA receptor subunit GluR1 in the spinal injured area of the rats with acute spinal cord injury / 中国针灸
Chinese Acupuncture & Moxibustion ; (12): 307-312, 2021.
Article in Chinese | WPRIM | ID: wpr-877610
ABSTRACT
OBJECTIVE@#To explore the influence of electroacupuncture (EA) on the expression of AMPA receptor subunit GluR1 in the rats with acute spinal cord injury (SCI) and explore the potential effect mechanism of EA in treatment of acute SCI.@*METHODS@#A total of 80 SD rats were randomly divided into five groups, i.e. a sham-operation group, a model group, an AMPA antagonist (DNQX) group, an EA group and a DNQX+EA group, 16 rats in each group. The modified Allen's impacting method was adopted to prepare the rat model of acute SCI at T@*RESULTS@#Compared to the sham-operation group in 6 h, 24 h and 48 h after modeling, the BBB scores were all significantly decreased in the model group (@*CONCLUSION@#The intervention with EA at "Dazhui" and "Mingmen" promotes the repair of the injured nerve in the spinal anterior horn probably through inhibiting GluR1 expression in the spinal injured area in the rats with acute SCI.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Cord / Spinal Cord Injuries / Electroacupuncture / Rats, Sprague-Dawley / Receptors, AMPA Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Acupuncture & Moxibustion Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Cord / Spinal Cord Injuries / Electroacupuncture / Rats, Sprague-Dawley / Receptors, AMPA Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Acupuncture & Moxibustion Year: 2021 Type: Article