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Mitochondrial Oxidative Stress Enhances Vasoconstriction by Altering Calcium Homeostasis in Cerebrovascular Smooth Muscle Cells under Simulated Microgravity / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 203-212, 2021.
Article in English | WPRIM | ID: wpr-878338
ABSTRACT
Objective@#Exposure to microgravity results in postflight cardiovascular deconditioning in astronauts. Vascular oxidative stress injury and mitochondrial dysfunction have been reported during this process. To elucidate the mechanism for this condition, we investigated whether mitochondrial oxidative stress regulates calcium homeostasis and vasoconstriction in hindlimb unweighted (HU) rat cerebral arteries.@*Methods@#Three-week HU was used to simulate microgravity in rats. The contractile responses to vasoconstrictors, mitochondrial fission/fusion, Ca @*Results@#An increase of cytoplasmic Ca @*Conclusion@#The present results suggest that mitochondrial oxidative stress enhances cerebral vasoconstriction by regulating calcium homeostasis during simulated microgravity.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vasoconstriction / Cerebral Arteries / Calcium / Rats, Sprague-Dawley / Weightlessness Simulation / Oxidative Stress / Myocytes, Smooth Muscle / Homeostasis / Mitochondria Type of study: Prognostic study Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vasoconstriction / Cerebral Arteries / Calcium / Rats, Sprague-Dawley / Weightlessness Simulation / Oxidative Stress / Myocytes, Smooth Muscle / Homeostasis / Mitochondria Type of study: Prognostic study Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2021 Type: Article