Correlation between gut microbiota and liver biochemical indicators in patients with chronic hepatitis B / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 301-311, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-878563
ABSTRACT
Chronic hepatitis B (CHB) is a global epidemic disease caused by hepatitis B virus that can lead to hepatic failure, even liver cirrhosis and hepatocellular carcinoma. The occurrence and development of CHB are closely related to the changes in the gut microbiota communities. To explore the relationship between the structure of gut microbiota and liver biochemical indicators, 14 CHB patients (the CHB group) and 11 healthy people (the CN group) were randomly enrolled in this study. Our results demonstrate that CHB caused changes in the gut microbiota communities and biochemical indicators, such as alanine transaminase, total bilirubin and gamma glutamyl transferase. Furthermore, CHB induced imbalance of the gut microbiota. Prevotella, Blautia, Ruminococcus, Eubacterium eligens group, Bacteroides uniformis and Ruminococcus sp. 5_1_39BFAA were associated with the critical biochemical indicators and liver injury, suggesting a new approach to CHB treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteroides
/
Hepatitis B virus
/
Hepatitis B, Chronic
/
Eubacterium
/
Gastrointestinal Microbiome
/
Liver Cirrhosis
/
Liver Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS