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Thirty years development of ¹³C metabolic flux analysis: a review / 生物工程学报
Chinese Journal of Biotechnology ; (12): 1510-1525, 2021.
Article in Chinese | WPRIM | ID: wpr-878652
ABSTRACT
¹³C metabolic flux analysis (¹³C-MFA) enables the precise quantification of intracellular metabolic reaction rates by analyzing the distribution of mass isotopomers of proteinogenic amino acids or intracellular metabolites through ¹³C labeling experiments. ¹³C-MFA has received much attention as it can help systematically understand cellular metabolic characteristics, guide metabolic engineering design and gain mechanistic insights into pathophysiology. This article reviews the advances of ¹³C-MFA in the past 30 years and discusses its potential and future perspective, with a focus on its application in industrial biotechnology and biomedicine.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Carbon Isotopes / Metabolic Engineering / Metabolic Flux Analysis / Amino Acids / Isotope Labeling / Models, Biological Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Carbon Isotopes / Metabolic Engineering / Metabolic Flux Analysis / Amino Acids / Isotope Labeling / Models, Biological Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article