Recent advances in developing enabling technologies for Corynebacterium glutamicum metabolic engineering / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1603-1618, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-878657
ABSTRACT
Corynebacterium glutamicum is an important workhorse of industrial biotechnology, especially for amino acid bioindustry. This bacterium is being used to produce various amino acids at a level of over 6 million tons per year. In recent years, enabling technologies for C. glutamicum metabolic engineering have been developed and improved, which accelerated construction and optimization of microbial cell factoriers, expanding spectra of substrates and products, and facilitated basic researches on C. glutamicum. With these technologies, C. glutamicum has become one of the ideal microbial chasses. This review summarizes recent key technological developments of enabling technologies for C. glutamicum metabolic engineering and focuses on establishment and applications of CRISPR-based genome editing, gene expression regulation, adaptive laboratory evolution, and biosensor technologies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biotechnology
/
Corynebacterium glutamicum
/
Metabolic Engineering
/
Gene Editing
/
Amino Acids
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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