Advances in metabolic engineering of non-conventional yeasts / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1659-1676, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-878660
ABSTRACT
Over the past 30 years, Yarrowia lipolytica, Kluyveromyces, Pichia, Candida, Hansenula and other non-conventional yeasts have attracted wide attention because of their desirable phenotypes, such as rapid growth, capability of utilizing multiple substrates, and stress tolerance. A variety of synthetic biology tools are being developed for exploitation of their unique phenotypes, making them potential cell factories for the production of recombinant proteins and renewable bio-based chemicals. This review summarizes the gene editing tools and the metabolic engineering strategies recently developed for non-conventional yeasts. Moreover, the challenges and future perspectives for developing non-conventional yeasts into efficient cell factories for the production of useful products through metabolic engineering are discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pichia
/
Yeasts
/
Yarrowia
/
Synthetic Biology
/
Metabolic Engineering
/
Gene Editing
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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