Critical quality attribute assessment of big brand traditional Chinese medicine: quality control of Tongren Niuhuang Qingxin Pills in texture and sensory attributes / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1598-1605, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-879067
ABSTRACT
Texture sensory attributes are the key items in quality control of Chinese medicinal honeyed pills. The purpose of this study is to develop a quality control method for assessing the texture sensory attributes of Chinese medicinal honeyed pills based on real-world Tongren Niuhuang Qingxin pilular masses and finished products. First, parameters of texture profile analysis(TPA) were optimized through single factor and central composite design(CCD) experiments to establish a detection method for texture sensory attri-butes of Tongren Niuhuang Qingxin Pills. The results showed that the established detection method was stable and reliable, with the optimal parameters set up as follows deformation percentage of 70%, detection speed at 30 mm·min~(-1), and interval time of 15 s. Furthermore, 540 data points yielded form six texture sensory attributes of pills from 30 batches were subjected to multivariate statistical process control(MSPC) with Hotelling T~2 and squared prediction error(SPE) control charts to establish the quality control method of Tongren Niuhuang Qingxin Pills. This study is expected to provide a reference for improving the quality control system of Chinese medicinal honeyed pills.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality Control
/
Drugs, Chinese Herbal
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
/
Prognostic study
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2021
Type:
Article
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