Advances about perineuronal nets in the repair of nerve function after spinal cord injury / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 91-96, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-879412
ABSTRACT
Perineuronal nets (PNNs) is a complex network composed of highly condensed extracellular matrix molecules surrounding neurons. It plays an important role in maintaining the performance of neurons and protecting them from harmful substances. However, after spinal cord injury, PNNs forms a physical barrier that surrounds the neuron and limits neuroplasticity, impedes axonal regeneration and myelin formation, and promotes local neuroinflammatory uptake. This paper mainly describes the composition and function of PNNs of neurons and its regulatory effects on axonal regeneration, myelin formation and neuroinflammation after spinal cord injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Spinal Cord Injuries
/
Axons
/
Extracellular Matrix
/
Nerve Regeneration
/
Neuronal Plasticity
/
Neurons
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2021
Type:
Article
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