Progress in genetic research on tooth agenesis associated with Wnt/beta-catenin signaling pathway / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 506-509, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-879615
ABSTRACT
Tooth agenesis is the most common form of congenital craniofacial dysplasia seen in stomatology clinics, which may be caused by genetic and/or environmental factors. Tooth development is regulated by a series of signaling pathways, and variants in any of these strictly balanced signaling cascades can result in tooth agenesis and/or other oral defects. Notably, variants of genes of the Wnt/beta-catenin signaling pathway are important cause for both non-syndromic and syndromic tooth agenesis. This article has provided a review for the molecular genetics of tooth agenesis associated with Wnt/beta-catenin signaling pathway, which may shed lights on the etiology and molecular mechanism of this disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tooth
/
Genetic Research
/
Wnt Proteins
/
Wnt Signaling Pathway
/
Anodontia
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2021
Type:
Article
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