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Clinical significance of minimal residual disease in B-lineage acute lymphoblastic leukemia pediatric patients with different fusion gene backgrounds / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1279-1285, 2020.
Article in Chinese | WPRIM | ID: wpr-879790
ABSTRACT
OBJECTIVE@#To study the clinical significance of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (B-ALL) pediatric patients with different fusion gene backgrounds.@*METHODS@#A retrospective analysis was performed on the medical data of 441 B-ALL children who were treated from January 2008 to April 2015. Among the 441 children, 336 had negative fusion gene, 79 had positive @*RESULTS@#In patients with negative fusion gene, the positive MRD group had significantly lower overall survival (OS) rate and event-free survival (EFS) rate (@*CONCLUSIONS@#MRD has the most definite prognostic significance in pediatric B-ALL patients with negative fusion gene, while it has unsatisfactory prognostic significance in those with positive
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Oncogene Proteins, Fusion / Retrospective Studies / Neoplasm, Residual / Homeodomain Proteins / Disease-Free Survival / Core Binding Factor Alpha 2 Subunit Type of study: Observational study / Prognostic study Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Oncogene Proteins, Fusion / Retrospective Studies / Neoplasm, Residual / Homeodomain Proteins / Disease-Free Survival / Core Binding Factor Alpha 2 Subunit Type of study: Observational study / Prognostic study Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article