Clinical significance of minimal residual disease in B-lineage acute lymphoblastic leukemia pediatric patients with different fusion gene backgrounds / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1279-1285, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-879790
ABSTRACT
OBJECTIVE@#To study the clinical significance of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (B-ALL) pediatric patients with different fusion gene backgrounds.@*METHODS@#A retrospective analysis was performed on the medical data of 441 B-ALL children who were treated from January 2008 to April 2015. Among the 441 children, 336 had negative fusion gene, 79 had positive @*RESULTS@#In patients with negative fusion gene, the positive MRD group had significantly lower overall survival (OS) rate and event-free survival (EFS) rate (@*CONCLUSIONS@#MRD has the most definite prognostic significance in pediatric B-ALL patients with negative fusion gene, while it has unsatisfactory prognostic significance in those with positive
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/
Oncogene Proteins, Fusion
/
Retrospective Studies
/
Neoplasm, Residual
/
Homeodomain Proteins
/
Disease-Free Survival
/
Core Binding Factor Alpha 2 Subunit
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2020
Type:
Article
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