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The Antileukemia Activity of ZSTK474 on U937 Cells / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 17-25, 2021.
Article in Chinese | WPRIM | ID: wpr-880025
ABSTRACT
OBJECTIVE@#To investigate the antileukemia activity of phosphatidylinositol-3 kinase (PI3K) inhibitor ZSTK474 on human leukemia cell line U937.@*METHODS@#MTT, soft agar assay, flow cytometric analysis and western blot were used to detect the effect of ZSTK474 on U937 cell proliferation, tumorigenicity, cell cycle, cell apoptosis and phosphorylation levels of the key factor of PI3K/AKT pathway. Chou-Talalay method was used to evaluate the combination of ZSTK474 with Cytarabine or Homoharringtonine.@*RESULTS@#PI3K inhibitor ZSTK474 could inhibit the proliferation and tumorigenicity of U937 cell, induce G@*CONCLUSION@#ZSTK474 can inhibit the pathway of PI3K/AKT, ZSTK474 alone or in combination with Homoharringtonine shows potential antileukemia activity on U937 cells.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Triazines / Apoptosis / Phosphatidylinositol 3-Kinases / U937 Cells / Cell Line, Tumor / Cell Proliferation / Proto-Oncogene Proteins c-akt / Glycogen Synthase Kinase 3 beta Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Triazines / Apoptosis / Phosphatidylinositol 3-Kinases / U937 Cells / Cell Line, Tumor / Cell Proliferation / Proto-Oncogene Proteins c-akt / Glycogen Synthase Kinase 3 beta Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article