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The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems
Acta Pharmaceutica Sinica B ; (6): 961-977, 2021.
Article in English | WPRIM | ID: wpr-881178
ABSTRACT
As one of the most important components of caveolae, caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways, and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction. In recent years, the relationship between the expression level of caveolin-1 in the tumor microenvironment and the prognostic effect of tumor treatment and drug treatment resistance has also been widely explored. In addition, the interplay between caveolin-1 and nano-drugs is bidirectional. Caveolin-1 could determine the intracellular biofate of specific nano-drugs, preventing from lysosomal degradation, and facilitate them penetrate into deeper site of tumors by transcytosis; while some nanocarriers could also affect caveolin-1 levels in tumor cells, thereby changing certain biophysical function of cells. This article reviews the role of caveolin-1 in tumor prognosis, chemotherapeutic drug resistance, antibody drug sensitivity, and nano-drug delivery, providing a reference for the further application of caveolin-1 in nano-drug delivery systems.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article