Error-related negativity in obsessive-compulsive disorder / 中华行为医学与脑科学杂志

ABSTRACT

Obsessive-compulsive disorder (OCD), which has the main clinical features of intrusive obsessions and compulsive behaviors, is listed as one of the top ten disabling diseases by the World Health Organization.Error related negativity(ERN) is a neurocognitive alarm signal in the case of errors.The individual differences in the ERN reflect the variability in reactivity to errors and to an internally generated threat.More and more studies have reported that ERN amplitudes in OCD have significantly increased.As a result, overactive error-monitoring is a core dysfunction disorder in OCD, which is closely related to the key symptoms of OCD including worry, doubt, repeating check behaviors.In addition, the increased ERN amplitudes are expected to serve as a diagnostic or predictive marker of OCD as well as a potential intervention target of this disease.Therefore, further understanding about the relationship between ERN and pathophysiology of OCD plays an important role in the effective diagnosis and treatment of OCD.The current paper aims to review the research results of ERN in patients with OCD and explore the following issues the common experiment paradigms of ERN in OCD, the brain region sources of ERN in OCD, the characteristic manifestations of ERN in OCD, influencing factors of ERN and clinical value and application of ERN in OCD.In a word, it will provide reference for clinical practice and scientific research in the future.