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The role of nicotinamide adenine dinucleotide phosphate oxidase in vascular cognitive impairment and its mechanism: a research progress / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12): 255-259, 2021.
Article in Chinese | WPRIM | ID: wpr-884878
ABSTRACT
Oxidative stress(OS)is one of the factors leading to vascular cognitive impairment(VCI). Reactive oxygen species(ROS)produced by Nicotinamide adenine dinucleotide phosphate oxidase(NOX)is an important pathogenic molecule of VCI.Risk factors for VCI such as hyperglycemia and decomposition/re-implantation always increases an upstream NOX activation.Other risk factors such as advanced age, hypertension and stroke are the downstream damage caused by NOX-dependent ROS.The causes of VCI include both risk factors related to NOX and the cell damage caused by NOX-dependent ROS.Studies have shown that the inhibiting of NOX activity can reduce cognitive impairment and the risk factors in animal models of VCI.In this article, we review the research progress of the role and mechanism of NOX in VCI.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2021 Type: Article