Your browser doesn't support javascript.
loading
Endogenous protective effects of arachidonic acid epoxygenase metabolites, epoxyeicosatrienoic acids, in cardiovascular system / 生理学报
Acta Physiologica Sinica ; (6): 617-630, 2021.
Article in Chinese | WPRIM | ID: wpr-887697
ABSTRACT
The morbidity and mortality of cardiovascular diseases are increasing annually, which is one of the primary causes of human death. Recent studies have shown that epoxyeicosatrienoic acids (EETs), endogenous metabolites of arachidonic acid (AA) via CYP450 epoxygenase, possess a spectrum of protective properties in cardiovascular system. EETs not only alleviate cardiac remodeling and injury in different pathological models, but also improve subsequent hemodynamic disturbances and cardiac dysfunction. Meanwhile, various studies have demonstrated that EETs, as endothelial-derived hyperpolarizing factors, regulate vascular tone by activating various ion channels on endothelium and smooth muscle, which in turn can lower blood pressure, improve coronary blood flow and regulate pulmonary artery pressure. In addition, EETs are protective in endothelium, including inhibiting inflammation and adhesion of endothelial cells, attenuating platelet aggregation, promoting fibrinolysis and revascularization. EETs can also prevent aortic remodeling, including attenuating atherosclerosis, adventitial remodeling, and aortic calcification. Therefore, it is clinically important to study the physiological and pathophysiological effects of EETs in the cardiovascular system to further elucidate the mechanisms, as well as provide new strategy for the prevention and treatment of cardiovascular diseases. This review summarizes the endogenous cardioprotective effects and mechanisms of EETs in order to provide a new insight for research in this field.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular System / Eicosanoids / Cytochrome P-450 Enzyme System / Endothelial Cells / 8,11,14-Eicosatrienoic Acid Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2021 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular System / Eicosanoids / Cytochrome P-450 Enzyme System / Endothelial Cells / 8,11,14-Eicosatrienoic Acid Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2021 Type: Article