Progress on mitochondrial silence information regulator family in epilepsy / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 403-408, 2021.
Article
in English
| WPRIM
| ID: wpr-888506
ABSTRACT
SIRT3, SIRT4 and SIRT5 are located in mitochondria and also known as mitochondrial sirtuins. They play important roles in regulating many cellular functions including cell survival, cell cycle or apoptosis, DNA repair and metabolism. Mitochondrial sirtuins are involved in the protection of mitochondrial integrity and energy metabolism under stress regulating the expression of neurotransmitter receptors, neurotrophins, extracellular matrix proteins and various transcription factors, thus involved in epileptogenesis triggered by both genetic or acquired factors. Here we review research progress on the actions of mitochondrial sirtuin in epilepsy; and discuss the challenges and perspectives of mitochondrial sirtuin as a potential therapeutic target for epilepsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apoptosis
/
Sirtuins
/
Epilepsy
/
Sirtuin 3
/
Mitochondria
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2021
Type:
Article
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