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Clinical Characteristics and Prognostic Factors of Primary FL Patients with Grade 3 or Large B Cell Transformation / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1169-1174, 2021.
Article in Chinese | WPRIM | ID: wpr-888534
ABSTRACT
OBJECTIVE@#To investigate the clinical characteristics and prognostic factors of primary follicular lymphoma (FL) patients with grade 3 or large B cell transformation, so as to provide more reference for the subsequent clinical diagnosis and treatment.@*METHODS@#Forty-seven primary FL patients with grade 3 or large B cell transformation from March 2010 to March 2018 were selected, the clinical characteristics and survival of patients were analyzed. Cox regression model were used to evaluate the related prognostic factors.@*RESULTS@#The cumulative progression-free survival rate and cumulative overall survival rate of 47 patients in 3-year follow-up reached to 55.32% (26/47) and 80.85% (38/47) respectively. There were significant differences in cumulative progression-free survival rate and cumulative overall survival rate among different subgroups of IPI, FLIPI-1 and FLIPI-2 in 3-year follow-up (P3 cm lymph node-involved site number≥3, extranodal lesion site number≥2, IPI score=2-3, FLIPI-1 score and FLIPI-2 score≥3 were the risk factors for progression-free survival (P<0.05); LDH≥240 U/ml, IPI score=2-3 and FLIPI-2 score≥3 were risk factors for overall survival (P<0.05). Cox regression model multivariate analysis showed that IPI score=2-3 was the independent risk factor for progression-free survival and overall survival (P<0.05). FLIPI-2 score≥3 was the independent risk factor for overall survival (P<0.05).@*CONCLUSION@#Primary FL patients with grade 3 or large B cell transformation by using the existing treatment regimen might be possibly curable, and the current treatment strategies and IPI score can be used to predict the clinical prognosis of patients.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / B-Lymphocytes / Survival Rate / Retrospective Studies / Risk Factors / Lymphoma, Follicular / Disease-Free Survival Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / B-Lymphocytes / Survival Rate / Retrospective Studies / Risk Factors / Lymphoma, Follicular / Disease-Free Survival Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article