Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study / 医学前沿
Frontiers of Medicine
;
(4): 438-447, 2021.
Article
in English
| WPRIM
| ID: wpr-888752
ABSTRACT
Thoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD remains unknown. Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population (N = 637). After population structure and genetic relationship and ancestry analyses, we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD. We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Cluster Analysis
/
Cohort Studies
/
Computational Biology
/
Genetic Predisposition to Disease
/
Collagen Type III
/
Aortic Dissection
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2021
Type:
Article
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