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Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 693-699, 2021.
Article in English | WPRIM | ID: wpr-888800
ABSTRACT
A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identification of fourteen secondary metabolites (1-14) including eight sesquiterpenoids (1-8) and six polyphenols (9-14). Compounds 1-3 were sesquiterpenes with new structures which were elucidated based on NMR spectroscopy, high resolution mass spectrometry (HRMS) and electronic circular dichroism (ECD) data. All the isolates were tested for their stimulation effects on glucose uptake in insulin-resistant HepG2 cells, and cellular antioxidant activity. Compounds 9-12 were subjected to molecular docking experiment to primarily evaluate their anti-coronavirus (SARS-CoV-2) activity. As a result, compounds 9-12 were found to increase the glucose uptake of insulin-resistant HepG2 cells by 18.1%, 62.7%, 33.7% and 21.4% at the dose of 50 μmol·L
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Sesquiterpenes / Basidiomycota / Agaricales / Polyphenols / Molecular Docking Simulation / SARS-CoV-2 / COVID-19 / Glucose / Antioxidants Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sesquiterpenes / Basidiomycota / Agaricales / Polyphenols / Molecular Docking Simulation / SARS-CoV-2 / COVID-19 / Glucose / Antioxidants Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2021 Type: Article