Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
Acta Pharmaceutica Sinica B
;
(6): 2738-2748, 2021.
Article
in English
| WPRIM
| ID: wpr-888885
ABSTRACT
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical practice. Increasing evidence suggests that CDKs, constituting a kinase family predominantly involved in cell cycle control, are synthetic lethal factors when combined with certain oncogenes, such as
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Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Acta Pharmaceutica Sinica B
Year:
2021
Type:
Article
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