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Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication
Gut and Liver ; : 338-345, 2021.
Article in English | WPRIM | ID: wpr-898464
ABSTRACT
The prevalence of gastric cancer after eradication (GCAE) is increasing dramatically in Japan. GCAE has characteristic features, and we must understand these features in endoscopic examinations. Differentiated cancer types were frequently found after eradication and included characteristic endoscopic features such as reddish depression (RD). However, benign RD can be difficult to distinguish from gastric cancer because of histological alterations in the surface structures (nonneoplastic epithelium or epithelium with low-grade atypia [ELA]) as well as multiple appearances of RD. Recently, we clarified similar alterations in genetic mutations between ELA and gastric cancer, suggesting that ELA is derived from gastric cancer. Clinically, submucosal invasive cancer was frequently found in patients after eradication therapy even if they received annual endoscopic surveillance. We can improve the diagnostic ability using image-enhanced endoscopy with magnified observation.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Screening study Language: English Journal: Gut and Liver Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Screening study Language: English Journal: Gut and Liver Year: 2021 Type: Article