Research Progress of Polypeptides Against Prostate Cancer / 中国实验方剂学杂志

ABSTRACT

Prostate cancer is an epithelial malignant tumor that occurs in the prostate. It is the most common cancer among men in the world. Its mortality rate is second only to lung cancer， which has seriously affected men's healthy life. Prostate cancer is not easy to be detected in the early stage. Most patients are already in the advanced stage and metastasized when they are diagnosed. At this time， radical surgery is not suitable for treatment. Advanced prostate cancer is mainly treated with endocrine therapy， but after a median time of 14-30 months， the patient will develop hormone-resistant prostate cancer and enter the advanced stage. Advanced hormone-resistant prostate cancer is treated with radiotherapy and chemotherapy， which， however， are not ideal for treating advanced prostate cancer. They can also cause serious side effects such as frequent urination， dysuria， urinary incontinence， rectal bleeding， loss of libido， hot flashes， and impotence， as well as generate multi-drug resistance. Therefore， it′s urgent to find a safe， effective and low-toxic anti-tumor drug. With the deepening of the research on the pharmacological effects of peptides， it has been proved that peptides have important application value in anti-fatigue， anti-aging， anti-inflammatory， antibacterial and anti-tumor. The anti-tumor peptides have attracted extensive attention in the field of anti-tumor research due to their high specificity， high bioavailability， good stability， low toxicity， low molecular weight， and easy synthesis. Pharmacological experiments have shown that polypeptides exert their anti-tumor effect mainly by inducing cell apoptosis， causing cell cycle arrest， inhibiting angiogenesis， and regulating immune function. This article summarized the related literature of peptides in recent years， the sources of peptides， the mechanisms and applications of peptides against prostate cancer for experimental research and clinical reference.