Non-antibacterial effects of macrolides and the application in the treatment of bronchiectasis / 国际儿科学杂志

ABSTRACT

Macrolide antibiotics have corresponding non-antibacterial effects in inhibiting inflammatory response, reducing airway mucus secretion, and reducing pathogen load.Bronchiectasis seriously affects the quality of life and growth of children.Currently, there is no specific treatment for bronchiectasis.Infection, chronic airway inflammation, and impaired mucociliary clearance are involved in the development of bronchiectasis.The non-antibacterial effects of macrolides in the treatment of cystic fibrosis, non-cystic fibrosis related bronchiectasis, and primary ciliary dyskinesia are reviewed in order to provide reference for pediatricians in clinical practice.