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Genetic diversity and molecular epidemiology of Bordetella pertussis isolates / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology ; (12): 687-691, 2021.
Article in Chinese | WPRIM | ID: wpr-912099
ABSTRACT

Objective:

To investigate the genetic diversity and molecular epidemiology of Bordetella pertussis in Shaanxi province, and analyze the possible reasons of resurgence in this region.

Methods:

We characterized clinical isolates collected during 2012-2017 using multilocus antigen sequence typing (MAST) and multilocus variable-number tandem repeat analysis (MLVA).

Results:

The circulating strains and vaccine strains were different in molecular characteristics. The majority (95%) of the isolates were typed as prn1/ ptxP1/ ptxA1/ fim3-1/ fim2-1. In addition, eight MLVA types (MTs) and eight PFGE profiles were identified, respectively. MT195, MT55 and MT104 were dominant and MT195 continually increased annually.

Conclusions:

The genetic characteristics of the current strains in Shaanxi province were different from those of the vaccine strain. The evolution through genetic variation might be one of the reasons for the recurrence of pertussis in this region.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Screening study Language: Chinese Journal: Chinese Journal of Microbiology and Immunology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Screening study Language: Chinese Journal: Chinese Journal of Microbiology and Immunology Year: 2021 Type: Article