Your browser doesn't support javascript.
loading
Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis
The Korean Journal of Parasitology ; : 777-783, 2015.
Article in English | WPRIM | ID: wpr-91222
ABSTRACT
The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Clonorchiasis / Clonorchis sinensis / Nitric Oxide Synthase Type II / Liver / Mice, Inbred BALB C Limits: Animals / Female / Humans Language: English Journal: The Korean Journal of Parasitology Year: 2015 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Clonorchiasis / Clonorchis sinensis / Nitric Oxide Synthase Type II / Liver / Mice, Inbred BALB C Limits: Animals / Female / Humans Language: English Journal: The Korean Journal of Parasitology Year: 2015 Type: Article