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Association of metformin use with risk and prognosis of esophageal cancer in patients with diabetes: A systematic review and meta-analysis / 中国胸心血管外科临床杂志
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery ; (12): 179-185, 2022.
Article in Chinese | WPRIM | ID: wpr-920818
ABSTRACT
@#Objective    To explore the relationship between metformin use and the risk and prognosis of esophageal cancer in patients with diabetes. Methods    The PubMed, Web of Science, EMbase, VIP, WanFang and CNKI databases were searched by computer to identify relevant studies from inception to August 21, 2021. Newcastle-Ottawa scale (NOS) was used to evaluate research quality. The STATA 12.0 software was used to conduct the statistical analysis. Results    A total of 14 studies involving 5 605 218 participants were included finally. NOS of all researches were≥6 points. The pooled results indicated that metformin use could decrease the risk of esophageal cancer in diabetics (OR=0.84, 95%CI 0.71-1.00, P=0.045), and could also prolong the overall survival of diabetics with esophageal cancer (HR=0.89, 95%CI 0.80-0.99, P=0.025). Conclusion    Metformin use can not only decrease the risk of esophageal cancer in patients with diabetes, but also improve the prognosis of diabetics with esophageal cancer significantly. However, more prospective high-quality studies are still needed to verify the conclusion.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Prognostic study / Systematic reviews Language: Chinese Journal: Chinese Journal of Clinical Thoracic and Cardiovascular Surgery Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Prognostic study / Systematic reviews Language: Chinese Journal: Chinese Journal of Clinical Thoracic and Cardiovascular Surgery Year: 2022 Type: Article