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Nomogram to predict pregnancy outcomes of emergency oocyte freeze-thaw cycles / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2306-2315, 2021.
Article in English | WPRIM | ID: wpr-921140
ABSTRACT
BACKGROUND@#Existing clinical prediction models for in vitro fertilization are based on the fresh oocyte cycle, and there is no prediction model to evaluate the probability of successful thawing of cryopreserved mature oocytes. This research aims to identify and study the characteristics of pre-oocyte-retrieval patients that can affect the pregnancy outcomes of emergency oocyte freeze-thaw cycles.@*METHODS@#Data were collected from the Reproductive Center, Peking University Third Hospital of China. Multivariable logistic regression model was used to derive the nomogram. Nomogram model performance was assessed by examining the discrimination and calibration in the development and validation cohorts. Discriminatory ability was assessed using the area under the receiver operating characteristic curve (AUC), and calibration was assessed using the Hosmer-Lemeshow goodness-of-fit test and calibration plots.@*RESULTS@#The predictors in the model of "no transferable embryo cycles" are female age (odds ratio [OR] = 1.099, 95% confidence interval [CI] = 1.003-1.205, P = 0.0440), duration of infertility (OR = 1.140, 95% CI = 1.018-1.276, P = 0.0240), basal follicle-stimulating hormone (FSH) level (OR = 1.205, 95% CI = 1.051-1.382, P = 0.0084), basal estradiol (E2) level (OR = 1.006, 95% CI = 1.001-1.010, P = 0.0120), and sperm from microdissection testicular sperm extraction (MESA) (OR = 7.741, 95% CI = 2.905-20.632, P 10 mm on the day of hCG administration.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Oocytes / Ovulation Induction / Pregnancy Outcome / Fertilization in Vitro / Retrospective Studies / Pregnancy Rate / Nomograms / Embryo Transfer Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Chinese Medical Journal Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oocytes / Ovulation Induction / Pregnancy Outcome / Fertilization in Vitro / Retrospective Studies / Pregnancy Rate / Nomograms / Embryo Transfer Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Chinese Medical Journal Year: 2021 Type: Article