2-Hexyl-4-Pentylenic Acid (HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 693-704, 2021.
Article
in En
| WPRIM
| ID: wpr-921320
Responsible library:
WPRO
ABSTRACT
Objective@#The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid (HPTA) in combination with radiotherapy (RT) on distant unirradiated breast tumors.@*Methods@#Using a rat model of chemical carcinogen (7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer, tumor volume was monitored and treatment response was evaluated by performing HE staining, immunohistochemistry, immunofluorescence, qRT-PCR, and western blot analyses.@*Results@#The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant, unirradiated breast tumors. The mechanism of action included tumor-associated macrophage (TAM) infiltration into distant tumor tissues, M1 polarization, and inhibition of tumor angiogenesis by IFN-γ.@*Conclusion@#The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors
Key words
Full text:
1
Index:
WPRIM
Main subject:
Cytokines
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Combined Modality Therapy
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Cell Proliferation
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Fatty Acids, Unsaturated
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Tumor-Associated Macrophages
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Mammary Neoplasms, Experimental
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Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2021
Type:
Article