Ionizing Radiation-Induced RPL23a Reduction Regulates Apoptosis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 789-802, 2021.
Article
in English
| WPRIM
| ID: wpr-921331
ABSTRACT
Objective@#The expression patterns of ribosomal large subunit protein 23a (RPL23a) in mouse testes and GC-1 cells were analyzed to investigate the potential relationship between RPL23a expression and spermatogonia apoptosis upon exposure to X-ray.@*Methods@#Male mice and GC-1 cells were irradiated with X-ray, terminal dUTP nick end-labelling (TUNEL) was performed to detect apoptotic spermatogonia @*Results@#Ionizing radiation (IR) increased spermatogonia apoptosis, the expression of RPL11, MDM2 and p53, and decreased RPL23a expression in mice spermatogonia @*Conclusion@#These results suggested that IR reduced RPL23a expression, leading to weakened the RPL23a-RPL11 interactions, which may have activated p53, resulting in spermatogonia apoptosis. These results provide insights into environmental and clinical risks of radiotherapy following exposure to IR in male fertility. The graphical abstract was available in the web of www.besjournal.com.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ribosomal Proteins
/
Spermatogonia
/
Signal Transduction
/
Gene Expression Regulation
/
Apoptosis
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS