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Antitumor Effects of Ethanol Extract from Ventilago leiocarpa Benth on Sarcoma 180 Tumor-Bearing Mice and Possible Immune Mechanism / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 905-911, 2021.
Article in English | WPRIM | ID: wpr-922105
ABSTRACT
OBJECTIVE@#To explore the antitumor effects of ethanol extract from Ventilago leiocarpa Benth (EEVLB) on sarcoma 180 (S180) tumor-bearing mice and the potential mechanism.@*METHODS@#Sixty mice were randomly assigned to 6 groups according to a random number table normal group, model group, 5-fluorouracil (5-FU) group (0.02 g·kg@*RESULTS@#EEVLB with different concentrations achieved inhibition of tumor growth in vivo, wherein the high-dose group showed the most significant reduction in tumor weight and increased apoptosis of tumor cells (P<0.05). In addition, both net weight gain and spleen index of mice showed uptrend in EEVLB treatment groups (P<0.05). Besides, serum levels of IL-2 and IL-6, percentages of CD3@*CONCLUSIONS@#EEVLB exhibits promising antitumor activity in vivo. This effect might be due to activation of apoptotic signaling pathway, increase of cytokine levels and enhancement of immune function in tumor-bearing mice.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sarcoma 180 / Plant Extracts / Rhamnaceae / Cell Line, Tumor / Ethanol Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sarcoma 180 / Plant Extracts / Rhamnaceae / Cell Line, Tumor / Ethanol Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2021 Type: Article