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Research Progress on Spread Through Air Spaces of Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 54-60, 2022.
Article in Chinese | WPRIM | ID: wpr-922155
ABSTRACT
The concept of spread through air spaces (STAS) was first proposed in the World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart (version 2015). STAS is defined as the micropapillary clusters, solid nests or single cells of tumor that exist in the air spaces of the surrounding lung parenchyma beyond the edge of the main tumor. Meanwhile, apart from the traditional invasion modes of lung adenocarcinoma (interstitial, visceral pleura and lym-phovascular invasion), STAS has been identified as the fourth invasion mode of lung adenocarcinoma. In recent years, the research on STAS has been a hot spot in the field of lung adenocarcinoma. The existence of STAS is related to lung cancer histopathology, gene mutation and other factors, and many studies have also confirmed that it can be used as an independent factor for tumor recurrence and prognosis. However, according to some studies, human factors can cause morphological artifacts of STAS, which still needs to be distinguished in clinical work. This paper reviews the research progress of STAS classification, related pathological features, genetic status changes, and human factors that may cause STAS artifacts.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Retrospective Studies / Adenocarcinoma of Lung / Lung Neoplasms / Neoplasm Invasiveness / Neoplasm Recurrence, Local / Neoplasm Staging Type of study: Observational study / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Retrospective Studies / Adenocarcinoma of Lung / Lung Neoplasms / Neoplasm Invasiveness / Neoplasm Recurrence, Local / Neoplasm Staging Type of study: Observational study / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2022 Type: Article