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Effects of Arsenic Disulfide Combined with Itraconazole on Proli- feration and Apoptosis and Hedgehog Pathway of Diffuse Large B-Cell Lymphoma Cells / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1504-1509, 2021.
Article in Chinese | WPRIM | ID: wpr-922286
ABSTRACT
OBJECTIVE@#To investigate the effect of arsenic disulfide (AS@*METHODS@#The human DLBCL cell OCI-LY3 was treated with different concentrations of AS@*RESULTS@#The DLBCL cell viability was decreased significantly at 24, 48 or 72 h as cultured with itraconazole. Along with the increasing of itraconazole concentration, the DLBCL cell viability was significantly reduced as compared with that in control group, and the results showed statistically significant(r=-0.690,r=-0.639, r=-0.833, r=-0.808, r=-0.578). The inhibitory and apoptosis rates of the cells were significantly increased as compared with those of the single drug-treated group after treated by the combination of itraconazole and AS@*CONCLUSION@#Itraconazole can inhibit proliferation of DLBCL cells in a concentration-and time-dependent manner. In addition, the combination of AS
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Arsenicals / Sulfides / Lymphoma, Large B-Cell, Diffuse / Apoptosis / Itraconazole / Hedgehog Proteins Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arsenicals / Sulfides / Lymphoma, Large B-Cell, Diffuse / Apoptosis / Itraconazole / Hedgehog Proteins Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article