Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells

Ying-Hua WANG; Meng YAN; Xi ZHANG; Xin-Yu LIU; Yi-Fu DING; Chong-Ping LAI; Ming-Han TONG; Jin-Song LI

Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells / 亚洲男科学杂志(英文版)

Ying-Hua WANG; Meng YAN; Xi ZHANG; Xin-Yu LIU; Yi-Fu DING; Chong-Ping LAI; Ming-Han TONG; Jin-Song LI.

Asian Journal of Andrology ; (6): 590-599, 2021.

Article in English | WPRIM | ID: wpr-922360

ABSTRACT

ABSTRACT

Azoospermia patients who carry a monogenetic mutation that causes meiotic arrest may have their biological child through genetic correction in spermatogonial stem cells (SSCs). However, such therapy for infertility has not been experimentally investigated yet. In this study, a mouse model with an X-linked testis-expressed 11 (TEX11) mutation (Tex11

Subject(s)

Animals; Male; Mice; Adult Germline Stem Cells/metabolism; Azoospermia/genetics; Infertility, Male/therapy; Mutation/genetics; Spermatogenesis/genetics

azoospermia; gene therapy; male infertility; meiotic arrest; spermatogonial stem cells; testis-expressed 11

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spermatogenesis / Azoospermia / Adult Germline Stem Cells / Infertility, Male / Mutation Limits: Animals Language: English Journal: Asian Journal of Andrology Year: 2021 Type: Article

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