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A small molecule UPR modulator for diabetes identified by high throughput screening
Acta Pharmaceutica Sinica B ; (6): 3983-3993, 2021.
Article in English | WPRIM | ID: wpr-922454
ABSTRACT
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones. In addition, UPR also enhances degradation of unfolded proteins and reduces global protein synthesis to alleviate additional accumulation of unfolded proteins in the ER. Herein, we describe a cell-based ultra-high throughput screening (uHTS) campaign that identifies a small molecule that can modulate UPR and ER stress in cellular and

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study / Screening study Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study / Screening study Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article