Effect of high-intensity interval exercise on depression-related behavior in mice / 生理学报
Acta Physiologica Sinica
;
(6): 165-176, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-927592
ABSTRACT
This paper was aimed to clarify the effect of high-intensity interval training (HIIT) on depression. Animal running platforms were used to establish HIIT exercise models, depression models were prepared by chronic unpredictable mild stress (CUMS), and depression-related behaviors were detected by behavioral experiments. The results showed that HIIT exercise improved depression-related behavior in CUMS model mice. Western blot and ELISA results showed that in the hippocampus, medial prefrontal cortex (mPFC) and amygdala of the CUMS model mice, glucocorticoid receptor (GR) protein expression was down-regulated, and the content of tumor necrosis factor α (TNF-α) was increased, compared with those in the control group, whereas HIIT exercise could effectively reverse these changes in CUMS model mice. These results suggest that HIIT exercise can exert antidepressant effect, which brings new ideas and means for the clinical treatment of depressive diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stress, Psychological
/
Behavior, Animal
/
Depression
/
Disease Models, Animal
/
Hippocampus
/
Antidepressive Agents
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2022
Type:
Article
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