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Advances in several important antimicrobial lipopeptids from Bacillus spp / 生物工程学报
Chinese Journal of Biotechnology ; (12): 1768-1783, 2022.
Article in Chinese | WPRIM | ID: wpr-927817
ABSTRACT
Bacillus spp. are probiotics and can secrete a variety of natural antimicrobiol active substances, of which lipopeptides are an important class. Up to now, about 90 lipopeptides have been identified, and most of them are cyclic lipopeptides. surfactin, iturin, fengycin, bacillomycin and polymyxins are widely studied, and the first three have huge potential for application due to their properties of surfactants and anti-fungal, anti-bacterial, anti-viral, anti-tumor and anti-inflammatory functions. In this paper, the research progress in the structure, function, synthesis regulation, separation, purification and production of surfactin, iturin and fengycin was reviewed. Synthetic biology is a vital means to increase the yield of lipopeptides, and in the future, lipopeptides can be used in crop cultivation, animal farming, food, medicine and petroleum industries as well as environmental protection. Future research should be strengthened on the discovery of new lipopeptides, synthesis of high-activity lipopeptides, economical production of lipopeptides on a large scale and their safety evaluation.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides, Cyclic / Bacillus / Bacillus subtilis / Lipopeptides / Anti-Infective Agents / Anti-Bacterial Agents Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides, Cyclic / Bacillus / Bacillus subtilis / Lipopeptides / Anti-Infective Agents / Anti-Bacterial Agents Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2022 Type: Article