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Association study of single nucleotide polymorphisms of AQP7 and AQP9 genes with type 2 diabetes mellitus among ethnic Han Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 234-239, 2022.
Article in Chinese | WPRIM | ID: wpr-928397
ABSTRACT
OBJECTIVE@#To assess the association of single nucleotide polymorphisms (SNP) of aquaporin 7 ( AQP7) and aquaporin 9 ( AQP9) genes and type 2 diabetes mellitus (T2DM) among ethnic Han Chinese population.@*METHODS@#A case-control study involving 1194 subjects with T2DM and 1274 non-diabetic mellitus (NDM) subjects were enrolled. Genotypes of three SNPs (rs3758269 of AQP7 gene, rs16939881 and rs57139208 of AQP9 gene) were determined by using a MassArray method. The association of the three SNPs with T2DM was assess, and the correlation of glucose and lipid metabolism parameters with various SNP genotypes in the NDM group was analyzed.@*RESULTS@#The allelic and genotypic frequencies of the three SNPs did not differ significantly between the two groups (P>0.05). Nor was there significant difference between the two groups with different genetic models (P>0.05). No significant association of genotypes of AQP7 gene rs3758269, AQP9 gene rs16939881 and rs57139208 with glucose and lipid metabolism parameters were observed in the NDM group (P>0.05).@*CONCLUSION@#The rs3758269 in AQP7 gene and rs16939881 and rs57139208 in AQP9 gene are not associated with the genetic susceptibility of T2DM among ethnic Han Chinese population.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Case-Control Studies / China / Genetic Predisposition to Disease / Aquaporins / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 Type of study: Observational study / Risk factors Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Case-Control Studies / China / Genetic Predisposition to Disease / Aquaporins / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 Type of study: Observational study / Risk factors Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2022 Type: Article