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STING1 in sepsis: Mechanisms, functions, and implications / 中华创伤杂志(英文版)
Chinese Journal of Traumatology ; (6): 1-10, 2022.
Article in English | WPRIM | ID: wpr-928475
ABSTRACT
Sepsis is a life-threatening clinical syndrome and one of the most challenging health problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated host immune response to infection, which can eventually lead to multiple organ failure and even death. As an adaptor transporter between the endoplasmic reticulum and Golgi apparatus, stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173) has been found to play a vital role at the intersection of innate immunity, inflammation, autophagy, and cell death in response to invading microbial pathogens or endogenous host damage. There is ample evidence that impaired STING1, through its immune and non-immune functions, is involved in the pathological process of sepsis. In this review, we discuss the regulation and function of the STING1 pathway in sepsis and highlight it as a suitable drug target for the treatment of lethal infection.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Shock, Septic / Autophagy / Sepsis / Immunity, Innate / Multiple Organ Failure Limits: Humans Language: English Journal: Chinese Journal of Traumatology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Shock, Septic / Autophagy / Sepsis / Immunity, Innate / Multiple Organ Failure Limits: Humans Language: English Journal: Chinese Journal of Traumatology Year: 2022 Type: Article