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Advances in relationship between cell senescence and atherosclerosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 95-101, 2022.
Article in English | WPRIM | ID: wpr-928660
ABSTRACT
Cellular senescence is a biological process associated with the degeneration of cell structure and function, which contribute to age-related diseases. Atherosclerosis is a chronic inflammatory disease that can cause a variety of cardiovascular disorders. In this article, we review the effects of cellular senescence on the development of atherosclerosis through diverse physiopathological changes, focusing on the alterations in senescent organelles and the increased senescence-associated secretory phenotype (SASP), and exploring the relevant therapeutic strategies for atherosclerosis by clearing senescent cells and reducing SASP, to provide new insights for the treatment of atherosclerosis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Aging / Cardiovascular Diseases / Chronic Disease / Cellular Senescence / Atherosclerosis / Senescence-Associated Secretory Phenotype Limits: Humans Language: English Journal: Journal of Zhejiang University. Medical sciences Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Aging / Cardiovascular Diseases / Chronic Disease / Cellular Senescence / Atherosclerosis / Senescence-Associated Secretory Phenotype Limits: Humans Language: English Journal: Journal of Zhejiang University. Medical sciences Year: 2022 Type: Article