Research Progress of Intercellular Mitochondrial Transfer in the Development of Hematological Malignant Tumors --Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 310-313, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-928711
ABSTRACT
In recent years, studies have found that mitochondrial transfer between leukemic cells and different types of cells in their bone marrow microenvironment, especially mesenchymal stem cells, plays a key role in the occurrence, development and drug resistance of hematological malignant tumors. This paper mainly introduces the role and latest research progress of mitochondrial transfer in acute and chronic myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma, and briefly describes the mechanism of drug resistance caused by mitochondrial transfer in leukemic cells during chemotherapy. The aim is to provide a new idea and theoretical basis for using intercellular mitochondrial transfer as a potential therapeutic target.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Hematologic Neoplasms
/
Tumor Microenvironment
/
Mesenchymal Stem Cells
/
Mitochondria
/
Multiple Myeloma
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2022
Type:
Article
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