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Expert consensus on ensartinib in the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 297-307, 2022.
Article in Chinese | WPRIM | ID: wpr-935214
ABSTRACT
The mutation rate of anaplastic lymphoma kinase (ALK) in patients with non-small cell lung cancer is 3% to 7%. Due to its low mutation rate and better long-term survival compared with epidermal growth factor receptor-positive non-small cell lung cancer patients, therefore, it's called "diamond mutation". At present, there are three generations of ALK tyrosine kinase inhibitor (TKI) drugs in the world. The first-generation ALK-TKI drug approved in China is crizotinib, and the second-generation drugs are alectinib, ceritinib and ensartinib. Among them, ensartinib is an ALK-TKI domestically developed, and its efficacy is similar to that of alectinib. The main adverse event is transient rash, and compliance to ensartinib is better from the perspective of long-term survival of patients. The manifestation of rash caused by ensartinib is different from that of other ALK-TKI drugs. In order to facilitate clinical application and provide patients with more treatment options, under the guidance of the Committee of Cancer Rehabilitation and Palliative Care of China Anti-Cancer Association, this article collects and summarizes the common adverse reactions of ensartinib. Based on the clinical practice, a clear adverse classification and specific treatment plan are formulated, in order to provide a corresponding reference for clinicians to make more comprehensive clinical decisions.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperazines / Pyridazines / Carbazoles / Carcinoma, Non-Small-Cell Lung / Consensus / Protein Kinase Inhibitors / Exanthema / Anaplastic Lymphoma Kinase / Lung Neoplasms Type of study: Practice guideline / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Oncology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperazines / Pyridazines / Carbazoles / Carcinoma, Non-Small-Cell Lung / Consensus / Protein Kinase Inhibitors / Exanthema / Anaplastic Lymphoma Kinase / Lung Neoplasms Type of study: Practice guideline / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Oncology Year: 2022 Type: Article