Culture of pluripotent stem cell-derived hepatocytes and organoids / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 244-248, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-935935
ABSTRACT
Liver is one of the most important organs in the human body. Liver diseases are also a major threat to human health and longevity. Hepatic decompensation treatment is quite difficult due to multiple reasons. Extracorporeal liver support devices are unable to solve this problem, and there is a severe shortage of orthotopic liver transplant donors. Study of pluripotent stem cell-derived hepatocytes and organoids can determine not only hepatocyte fate, but also liver development, regeneration mechanisms, and pathophysiology. Furthermore, it can be used for drug screening in order to provide a stable source of functional hepatocytes for future transplantation therapy. Culture of pluripotent stem cell-derived hepatocytes and organoids has a self-organizing process similar to liver development, i.e., starting with changes in several key factors, and eventually forming functionally complex cells/organs. This paper introduces the main methods and progress of pluripotent stem cell-derived hepatocytes and organoids, with hope to provide clues for future research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organoids
/
Cell Differentiation
/
Hepatocytes
/
Pluripotent Stem Cells
/
Induced Pluripotent Stem Cells
/
Liver
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2022
Type:
Article
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