Progress in replicative senescence of mesenchymal stem cells regulated by microenvironment / 生理学报
Acta Physiologica Sinica
;
(6): 469-478, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-939581
ABSTRACT
Mesenchymal stem cells (MSCs) are a class of pluripotent cells that can self-renew and differentiate. Numerous studies have shown that MSCs have important roles in areas such as regenerative medicine and tissue engineering. However, it is worth noting that MSCs will gradually age during long-term in vitro expansion with decreased stemness such as weakened migration ability, slowed proliferation rate and decreased differentiation potential, which greatly hinders the application of MSCs. Currently, the microenvironment for cell growth is recognized as one of the factors causing senescence in MSCs. Recent studies point out that the latest technologies such as exogenous administration, oxygen concentration regulation and extracellular matrix (ECM) construction can delay stem cell senescence by simulating or regulating the microenvironment. Here, we review the current knowledge of the characteristics and molecular mechanisms of senescent MSCs and microenvironment strategies to maintain MSCs stemness, which can provide a reference for future large-scale application of MSCs preparations in tissue engineering and clinical studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Differentiation
/
Cells, Cultured
/
Cellular Senescence
/
Cell Proliferation
/
Extracellular Matrix
/
Mesenchymal Stem Cells
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2022
Type:
Article
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