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Pharmacological action of quercetin against testicular dysfunction: A mini review / 中西医结合学报
Journal of Integrative Medicine ; (12): 396-401, 2022.
Article in English | WPRIM | ID: wpr-939904
ABSTRACT
The testis is an immune-privileged organ susceptible to oxidative stress and inflammation, two major factors implicated in male infertility. A reduction in the concentration and activities of testicular function biomarkers has been shown to correlate with impaired hypothalamic-pituitary-testicular axis and oxidative stress. However, the use of natural products to ameliorate these oxidative stress-induced changes may be essential to improving male reproductive function. Quercetin possesses several pharmacological activities that may help to combat cellular reproduction-related assaults, such as altered sperm function and reproductive hormone dysfunction, and dysregulated testicular apoptosis, oxidative stress, and inflammation. Studies have shown that quercetin ameliorates testicular toxicity, largely by inhibiting the generation of reactive oxygen species, with the aid of the two antioxidant pharmacophores present in its ring structure. The radical-scavenging property of quercetin may alter signal transduction of oxidative stress-induced apoptosis, prevent inflammation, and increase sperm quality in relation to the hormonal concentration. In this review, the therapeutic potential of quercetin in mediating male reproductive health is discussed.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quercetin / Semen / Testis / Lipid Peroxidation / Apoptosis / Oxidative Stress / Inflammation / Antioxidants Limits: Humans / Male Language: English Journal: Journal of Integrative Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quercetin / Semen / Testis / Lipid Peroxidation / Apoptosis / Oxidative Stress / Inflammation / Antioxidants Limits: Humans / Male Language: English Journal: Journal of Integrative Medicine Year: 2022 Type: Article