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Identification of chemical constituents in Fufang Shechuangzi Xiji(Lotion)by UPLC-Q-TOF-MS/MS / 中国药科大学学报
Journal of China Pharmaceutical University ; (6): 452-466, 2022.
Article in Chinese | WPRIM | ID: wpr-939970
ABSTRACT
@#Fufang Shechuangzi Xiji (Lotion) is a common hospital preparation made from clinical prescriptions. Its clinical efficacy is accurate, yet its pharmacodynamic material basis has not been clarified.An ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technique was developed to identify the chemical constituents of Fufang Shechuangzi Xiji (Lotion).The chemical constituents of Fufang Shechuangzi Xiji (Lotion) were scanned by electrospray ionization (ESI) source in positive and negative ion modes.As a result, a total of 118 compounds were identified and characterized via reference standards and by comparing mass spectrometry data with literature, including 45 alkaloids, 21 coumarins and chromones, 19 flavonoids, 14 saponins, 10 anthraquinones and 9 organic acids.As a result, UPLC-QTOF-MS/MS technology can quickly and sensitively identify the chemical constituents of Fufang Shechuangzi Xiji (Lotion), which provides a useful reference for exploring the pharmacodynamic material basis and further quality control study of the preparation.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Practice guideline Language: Chinese Journal: Journal of China Pharmaceutical University Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Practice guideline Language: Chinese Journal: Journal of China Pharmaceutical University Year: 2022 Type: Article