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Correlation between serum magnesium and intracranial atherosclerotic stenosis / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases ; (12): 414-419, 2022.
Article in Chinese | WPRIM | ID: wpr-954148
ABSTRACT

Objective:

To investigate the correlation between serum magnesium and intracranial atherosclerotic stenosis (ICAS).

Methods:

The suspected patients with stroke treated in the Department of Neurology, Qingdao Municipal Hospital from January 2014 to June 2018 were retrospectively collected. The baseline characteristic data were collected and ICAS was evaluated by magnetic resonance angiography. Multivariate logistic regression model was used to analyze the independent correlation between serum magnesium and ICAS.

Results:

A total of 2 354 patients were enrolled, including 1 451 patients with acute ischemic stroke (ICAS n=416) and 903 patients with non-acute ischemic stroke (ICAS n=184). The median age of the overall study population was 67 years old (interquartile range, 60-77 years), 1 420 patients were male (60.30%), and the median serum magnesium was 0.86 mg/L (interquartile range, 0.81-0.92 mg/L). In patients with ischemic stroke, serum magnesium in the ICAS group was significantly lower than that in the non-ICAS group ( P=0.013); in patients with non-ischemic stroke, serum magnesium in the ICAS group tended to be lower than that in the non-ICAS group ( P=0.057). Multivariable logistic regression analysis showed that age (odds ratio [ OR] 1.020, 95% confidence interval [ CI] 1.010-1.030; P<0.001), hypertension ( OR 1.393, 95% CI 1.048-1.851; P=0.023) and diabetes ( OR 1.444, 95% CI 1.133-1.841; P=0.003) were the independent risk factors for ICAS in patients with ischemic stroke, while serum magnesium ( OR 0.252, 95% CI 0.064-0.996; P=0.049) was an independent protective factor of ICAS in patients with ischemic stroke.

Conclusion:

Lower serum magnesium is associated with higher risk of ICAS.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Cerebrovascular Diseases Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Cerebrovascular Diseases Year: 2022 Type: Article