Nitric oxide and pulmonary hypertension / 대한마취과학회지
Korean Journal of Anesthesiology
; : 4-14, 2010.
Article
in En
| WPRIM
| ID: wpr-95946
Responsible library:
WPRO
ABSTRACT
Pulmonary hypertension is a serious complication of a number of lung and heart diseases that is characterized by peripheral vascular structural remodeling and loss of vascular tone. Nitric oxide can modulate vascular injury and interrupt elevation of pulmonary vascular resistance selectively; however, it can also produce cytotoxic oxygen radicals and exert cytotoxic and antiplatelet effects. The balance between the protective and adverse effects of nitric oxide is determined by the relative amount of nitric oxide and reactive radicals. Nitric oxide has been shown to be clinically effective in the treatment of congenital heart disease, mitrial valvular disease combined with pulmonary hypertension and in orthotropic cardiac transplantation patients. Additionally, new therapeutic modalities for the treatment of pulmonary hypertension, phosphodiesterase inhibitors, natriuretic peptides and aqueous nitric oxide are also effective for treatment of elevated pulmonary vascular resistance.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Phosphodiesterase Inhibitors
/
Vascular Resistance
/
Heart Transplantation
/
Reactive Oxygen Species
/
Natriuretic Peptides
/
Vascular System Injuries
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Heart Diseases
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Hypertension, Pulmonary
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Lung
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Nitric Oxide
Limits:
Humans
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2010
Type:
Article