Research Progress of Regulatory T Cells in the Pathogenesis of Multiple Myeloma --Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 297-300, 2023.
Article
in Zh
| WPRIM
| ID: wpr-971140
Responsible library:
WPRO
ABSTRACT
The multiple myeloma (MM), the second most common hematologic malignancy, is malignant proliferative disease of plasma cells. Although the application of many targeted drugs has significantly prolonged the survival time of MM patients, it is still an incurable disease. In recent years, the immunosuppression caused by interaction between tumor microenvironment(TME) and tumor cells has attracted people's attention gradually. As a kind of immunosuppressive cells in TME, regulatory T cells (Treg) play an important role in the progress of MM. Treg is related to the proliferation and metastasis of tumors, and can lead to the progress of MM by promoting the angiogenesis and generating immunosuppressive TME. In this review, we briefly summarized the latest research progress on the impact of Treg on the pathogenesis of MM.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma Cells
/
Immunosuppression Therapy
/
T-Lymphocytes, Regulatory
/
Tumor Microenvironment
/
Immune Tolerance
/
Multiple Myeloma
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2023
Type:
Article