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Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Intestinal Research ; : 87-93, 2019.
Article in English | WPRIM (Western Pacific) | ID: wprim-740027
Responsible library: WPRO
ABSTRACT

BACKGROUND/AIMS:

Oral mesalazine is an important treatment for ulcerative colitis (UC), and non-adherence to mesalazine increases the risk of relapse. Controlled-release (CR) mesalazine has 2 formulations: tablets and granules. The relative acceptabilities of these formulations may influence patient adherence; however, they have not been compared to date. This study aimed to evaluate the acceptabilities of the 2 formulations of CR mesalazine in relation to patient adherence using a crossover questionnaire survey.

METHODS:

UC patients were randomly assigned to 2 groups in a 1:1 ratio. Patients in each group took either 4 g of CR mesalazine tablets or granules for 6 to 9 weeks, and then switched to 4 g of the other formulation for a further 6 to 9 weeks. The acceptability and efficacy were evaluated by questionnaires, and adherence was assessed using a visual analog scale. The difference in acceptabilities between the 2 formulations and its impact on adherence were assessed.

RESULTS:

A total of 49 patients were prospectively enrolled and 33 patients were included in the analysis. Significantly more patients found the tablets to be less acceptable than the granules (76% vs. 33%, P=0.0005). The granules were preferable to the tablets when the 2 formulations were compared directly (73% vs. 21%, P=0.004), for their portability, size, and numbers of pills. The adherence rate was slightly better among patients taking the granules (94% vs. 91%) during the observation period, but the difference was not significant (P=0.139).

CONCLUSIONS:

CR mesalazine granules are more acceptable than tablets, and may therefore be a better option for long-term medication.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Tablets / Ulcer / Humans / Patient Acceptance of Health Care / Colitis, Ulcerative / Prospective Studies / Patient Compliance / Mesalamine / Drug Compounding Clinical aspect: Diagnosis / Prognosis Language: English Journal: Intestinal Research Year: 2019 Type: Article