Effect of Korean Red Ginseng on the Relaxation of Clitoral Corpus Cavernosum in Rabbit / 대한남성과학회지
Korean Journal of Andrology
; : 29-34, 2006.
Article
in Ko
| WPRIM
| ID: wpr-18273
Responsible library:
WPRO
ABSTRACT
PURPOSE: The purposes of this study were to investigate the effect of Korean Red Ginseng(KRG) extract on the relaxation of the clitoral corpus cavernosal smooth muscle in rabbit. MATERIALS AND METHODS: Rabbit clitoral corpus cavernosal smooth muscle strips were mounted in organ chambers to measure isometric tension. The strips were contracted with phenylephrine(5 x 10(-6) M), and the responses to KRG extract(1~20 mg/ml), nitric oxide inhibitor(N omega-nitro-L-arginine methyl ester, L-NAME), vasoactive intestinal peptide(VIP) receptor antagonist, KCl were examined. The cGMP content of the strips was measured by radioimmunoassay after various dose of KRG extract. RESULTS: The KRG extract(1~20 mg/ml) relaxed the clitoral corpus cavernosal smooth muscle in a dose-dependent manner up to 95%. The relaxation effect of KRG extract was significantly inhibited by L-NAME(10(-4) M) in clitoral corpus cavernosal smooth muscle. The KRG extract also inhibited the contraction induced by depolarization with 10, 20, 40 mM of KCl. The KRG extract(1, 5 mg/ml) increased the accumulation of cGMP in clitoral corpus cavernosal smooth muscle. CONCLUSIONS: These data suggest that KRG extract has a relaxing effect on the clitoral corpus cavernosal smooth muscle in rabbit. These effects are in part mediated by the NO-cGMP pathway and a hyperpolarizing action.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Relaxation
/
Radioimmunoassay
/
Clitoris
/
Panax
/
Muscle, Smooth
/
Nitric Oxide
Limits:
Animals
Language:
Ko
Journal:
Korean Journal of Andrology
Year:
2006
Type:
Article